Millwood (2-4) came off the disabled list and pitched five shutout innings. The right-hander had been sidelined since May 26 with a strained right groin.
He gave up four hits, walked two and struck out five -- then got solid relief from Cleveland's reliable bullpen.
"It's a real thrill," Millwood told reporters when asked about getting win No. 100 -- and second since signing as a free agent with Cleveland in January. "We're starting to have fun here."
Grady Sizemore (.309) continued to lead the Indians, who have won nine of 10 and 17 of 24. He went 2-for-4 with a stolen base, scored one run and drove in another.
Aaron Boone doubled to open the third inning, took third on a groundout by Alex Cora, and scored on Sizemore' single to right. Sizemore then stole second and scored on another single to right by Coco Crisp.
Scott Sauerbeck pitched a scoreless sixth, but Bobby Howry yielded Ryan Shealy's first major-league homer leading off the seventh to make it 2-1. Howry got the next three batters, Arthur Rhodes pitched a scoreless eighth and Bob Wickman worked a scoreless ninth for his 18th save in 21 chances.
The Burlington Indians began exhibition play with an 8-8 tie against the Kernersville Bulldogs on Thursday night. Nick Petrucci's one-out single scored P.J. Hiser to tie it. Petrucci, a third baseman, was picked by the Cleveland Indians in the 11th round 10 days ago. Veterans Evandy DeLeon and Enrique Vasquez hit homers for Burlington. Veteran Edgar Morffe struck out five of the seven batters he faced over 2 1/3 innings of relief. Burlington will play another exhibition game Saturday night and open the season next Tuesday.
CLASS AAA BUFFALO (41-26) was blasted at Indianapolis, 12-7. Jeremy Guthrie (6-6, 6.34 ERA) had his string of decent outings snapped as he gave up six runs and eight hits over 2 1/3 innings. Kazuhito Tadano (4.58 ERA) continued his recent struggles by giving up six more runs (five earned) and seven hits over 4 2.3 innings before Andrew Brown (4.59 ERA) pitched one scoreless inning. Jason Cooper (.263) hit his second homer since being promoted from Class AA Akron and Jeff Liefer (.305) hit his 13th, a two-run shot. Jake Gautreau (.295) went 2-for-5 and scored twice, Ryan Garko (.279) went 2-for-4 and Mike Kinkade (.283) drove in two runs.
CLASS AA AKRON (39-26) had the day off. The Aeros, who lead the Southern Division of the Eastern League by four games, open a seven-game homestand and a three-game series against Bowie on Friday night at Canal Park.
CLASS A KINSTON (39-28) rallied to edge visiting Lynchburg, 5-4, as Nate Panther's two-run homer with two outs in the bottom of the ninth capped a four-run rally. Dave Wallace (.184) hit his seventh homer with one out to start the rally. Another run scored on a fielding error, then with one on and two outs, Panther (.269) connected for his ninth homer to win it. Wallace and Brandon Pinckney (.231) both went 2-for-4 for the K-Tribe. Jim Ed Warden (2-1, 4.68 ERA) pitched two scoreless innings to win it. Starter Sean Smith (3.81 ERA) gave up four runs on three hits and three walks over five innings. Juan Lara (4.26 ERA) then worked two scoreless innings, giving up one hit and two walks while striking out three.
CLASS A LAKE COUNTY (39-28) rolled to a 12-5 win over first-place Lexington, tying Hagerstown for second place, just one game back. The Captains broke a 5-5 tie with a five-run seventh inning and went on to win for the 10th time in 13 games. Brian Finegan (.284) went 3-for-5, scored four runs and drove in three -- two of them with his fourth homer. Mike Butia (.259) also went 3-for-5 with one run and one RBI, while Brian Barton just kept pounding the ball. Barton (.423) went 2-for-3 with two runs, two RBI and two walks. Wyatt Toregas (.230) and Chris Gimenez (.225) both had two hits, with Gimenez getting his eighth homer. Scott Roehl (4-3, 2.45 ERA) got the win by pitching 2 2/3 scoreless innings of relief of starter Reid Santos (5.75 ERA), who gave up 10 six hits and five runs (only three earned) over six innings. Brandon Rickert (5.09 ERA) struck out the only man he faced.